Monodentate Optically Active Phosphine Ligand

The optically active monodentate phosphine ligand 1, developed by Hayashi et al., forms optically active metal complex catalysts with transition metals.¹⁾ In particular, palladium complexes of 1 are used for the highly regioselective and highly enantioselective hydrosilylation of olefins. The obtained hydrosilylation products 2 are readily transformed into the secondary alcohols 3 by the Tamao oxidation.²⁾ This use of 1 has frequently been utilized as a procedure to obtain optically active alcohols from prochiral olefins. For example, optically active exo-norbornanol, which is an important raw material for making a variety of bioactive compounds, can be obtained from norbornene in highyield.³⁾

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