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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Chemistry News January 2025 | [Product Highlights] o-Nitrobenzyl Photolabile... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)

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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Chemistry News January 2025 | [Product Highlights] o-Nitrobenzyl Photolabile... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)

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一种可用于芳香C-H键活化的易修饰且无痕的导向基

由Gevorgyan等人研发出的2-(diisopropylsilyl)pyridine (PyDipSiH) 是一种可以有效引入导向基的试剂，通过在芳香环上引入吡啶基二异丙基硅烷基 (PyDipSi)，它可用于芳香C-H键的区域选择性活化反应。在芳基锂衍生物存在下，通过使用PyDipSiH进行处理，PyDipSi基团被直接引入到芳烃上。之后，由于吡啶基上的氮原子的配位作用，得到的芳烃的邻位上的C-H键能够被活化。在钯催化的C-H键活化反应中，可以发生邻位选择性酰氧基化反应和卤化反应。就像可以通过AgF盐来消去导向基那样，PyDipSi导向基也可以进一步转化为其他官能团，如碘和硼酸盐等。

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