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Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Chemistry News January 2025 | [TCIPracticalExample] 2,2,2-Trifluoroethyl Etherification Using... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)

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不饱和丁内酯对α,β不饱和硫代酰胺的不对称催化插烯共轭加成反应

柴等人已经报道了使用软Lewis酸/Bronsted碱为协同催化剂，不饱和丁内酯对α,β不饱和硫代酰胺的不对称催化插烯共轭加成反应。根据他们的结果，该反应通过使用[Cu(CH₃CN)₄]PF₆作为软Lewis酸，(R)-SEGPHOS为配体，及叔胺为Bronsted碱高对映选择性进行反应，生成共轭加成的连续三位和四位取代手性中心。该反应可在室温下进行且该产品的硫代酰胺官能团可转化为各种官能团。由于在大量天然产物和生物活性化合物中都可发现丁烯酸内酯结构，该反应有期望成为这些化合物合成的有效方法。

文献

L. Yin, H. Takada, S. Lin, N. Kumagai, M. Shibasaki, Angew. Chem. Int. Ed. 2014, 53, 5327.