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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Product Document Searching Made Easy by 2D Code! | TCI Life Science News December 2024 | [TCIPracticalExample] Reduction of Amide Group Using... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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三级醇到三级烷基异腈的立体翻转
Shenvi等人报道了三级醇到三级烷基异腈和胺的立体化学翻转。在该报告中，相应的三级醇经三氟乙酰化后，在Sc(OTf)3催化下，和过量的TMSCN发生反应生成三级烷基异腈，反应过程伴随手性翻转。与SN2反应相反，该反应对三级醇的化学选择性优先于一级醇或二级醇。因此，它可以用来补充Mitsunobu反应的选择性。
