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丙二酸酯和N-叔丁氧羰基亚胺的对映选择性Mannich反应
Karimi等人报道了丙二酸酯和N-叔丁氧羰基亚胺的对映选择性Mannich反应。结果显示，使用催化剂Yb(OTf)3和手性配体(R,R)-2,6-bis(4-isopropyl-2-oxazolin-2-yl)pyridine下，该对映选择性反应能够在室温下顺利进行，生成相应的β-氨基羰基化合物，且反应产率很高。反应结束后，由于含有活性次甲基部分，生成的产品能够用于链延长反应，随后脱二氧化碳生成β-氨基酸。因此，这个合成方法预计可以用于各种手性砌块的合成。
