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CAS RN: 3690-10-6 | 产品编码: Z0022
Zebularine

产品编码 | Z0022 |
纯度/分析方法 | >98.0%(T)(HPLC) |
分子式/分子量 | C__9H__1__2N__2O__5 = 228.20 |
外观与形状(20°C) | 固体 |
储存温度 | 冷藏 (0-10°C) |
应避免的情况 | 加热 |
包装和容器 | 1G-Glass Bottle with Plastic Insert (查看图片), 200MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 3690-10-6 |
Reaxys-RN | 751056 |
PubChem物质ID | 253660306 |
MDL编号 | MFCD04973699 |
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
Specific rotation [a]20/D | +156 ~ +166 deg(C=1, MeOH) |
物性(参考值)
熔点 | 158 °C(dec.) |
比旋光度 [α]D | 158° (C=1,MeOH) |
GHS
相关法规
RTECS# | UW7539720 |
运输信息
HS编码* | 2934.99-000 |
应用
Zebularine: An Effective Inhibitor of DNA Methylation
The main epigenetic modification is DNA methylation, and patterns of aberrant DNA methylation are now recognized to be a common hallmark of tumor cells. Zebularine, which is structurally 4-deamino cytidine, is a recently discovered mechanism-based inhibitor of DNA methylation. It is an effective inhibitor of cytidine deaminase and DNA cytosine methyltransferase.
References
- Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases
- Inhibition of DNA methylation and reactivation of silenced genes by zebularine
- Preferential response of cancer cells to zebularine
- Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
- Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
- The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
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