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CAS RN: 55778-02-4 | 产品编码: W0017
WZ 811
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 25MG |
S$240.00
|
24 | 3 |
|
| 100MG |
S$648.00
|
33 | 3 |
|
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 188.0 to 192.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 190 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相关法规
运输信息
| HS编码* | 2933.39-000 |
应用
WZ811: A CXC Chemokine Receptor Type 4 (CXCR4) Antagonist
WZ811 is known as an antagonist of CXC chemokine receptor type 4 (CXCR4), which is a chemokine receptor expressed on immune cells and cancer cells. CXCR4 is activated by its chemokine ligand CXCL12 (also known as SDF-1), and regulates many physiological and developmental processes such as hematopoietic cell trafficking. .CXCR4 is also one of the main co- receptors for human immunodeficiency virus (HIV) entry into T cells. Recently, it has been reported that CXCR4 induces migration of cancer cells and is important for processes such as metastasis. Therefore, CXCR4 antagonists are expected to regulate these tumor metastatic processes. (The product is for research purpose only.)
References
- Discovery of Small Molecule CXCR4 Antagonists
- Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors
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