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CAS RN: 69388-84-7 | 产品编码: U0159
Sulbactam Sodium
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| 产品编码 | U0159 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__8H__1__0NNaO__5S = 255.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 69388-84-7 |
| Reaxys-RN | 3599871 |
| MDL编号 | MFCD01750374 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation | +219 to +233 deg(C-1, water) |
| Water | max. 1.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 190 °C |
GHS
相关法规
| RTECS# | XH9220000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Sulbactam Sodium: A β-Lactamase Inhibitor Used with Another Antibiotic
Sulbactam [S0868] and its sodium salt are β-lactamase inhibitors which are chemically synthesized from 6-APA [A0800]. Although they have low antimicrobial activity, they inhibit enzymes (β-lactamases) which are produced by bacteria to degrade β-lactam antibiotics such as penicillins and cephalosporins. They are often used in combination with amoxicillin [A2099] or cefoperazone [C2768] to increase the antibiotic spectrum of theirs. (The product is for research purpose only.)
References
- Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases
- A Structure-Based Analysis of the Inhibition of Class A β-Lactamases by Sulbactam
- Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics (a review)
- Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations (a review)
- Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition (a review)
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