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CAS RN: 83105-70-8 | 产品编码: U0097
Sultamicillin Tosylate Dihydrate
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| 产品编码 | U0097 |
| 纯度/分析方法 | >98.0%(GC)(T) |
| 分子式/分子量 | C__2__5H__3__0N__4O__9S__2·C__7H__8O__3S·2H__2O = 802.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 83105-70-8 |
| 相关CAS RN | 76497-13-7 |
| Reaxys-RN | 25499733 |
| PubChem物质ID | 354335315 |
| Merck Index (14) | 8992 |
| MDL编号 | MFCD01682151 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +168 to +186 deg(C=0.5, water/CH3CN 3:2) |
物性（参考值）
| 比旋光度 [α]D | 177° (C=0.5,H2O/HcN=3:2) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | XH8460000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Sultamicillin Tosylate: The Mutual Prodrug of Ampicillin and Sulbactam
Sultamicillin tosylate is a double ester mutual prodrug in which ampicillin [A2092] and the β-lactamase inhibitor sulbactam [S0868] are linked via a methylene group. Sultamicillin is readily absorbed and hydrolyzed by enzymes in the intestinal wall, releasing ampicillin and sulbactam. Ampicillin is an aminopenicillin which exerts its bactericidal activity by inhibiting transpeptidase, an enzyme responsible for the synthesis of the peptidoglycan layer of the bacterial cell wall. Sulbactam is an irreversible inhibitor of many plasmid-mediated and some chromosomal β-lactamases, produced by resistant bacteria. Therefore, sultamicillin is effective against a wide range of gram-positive and gram-negative bacteria including Staphylococcus aureus and Staphylococcus epidermidis, including penicillin-resistant and some methicillin-resistant strains. (The product is for research purpose only.)
References
- Sultamicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use
- Role of sultamicillin and ampicillin/sulbactam in the treatment of upper and lower bacterial respiratory tract infections (a review)
- HPLC determination of sulbactam, sultamicillin tosylate, cefaclor, ampicillin and cefoperazone in pharmaceutical preparations
- Quantitative determination of sultamicillin p-toluenesulfonate in pharmaceutical preparations by reversed-phase high-performance liquid chromatography
- HPLC for in-process control in the production of sultamicillin
参考文献
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