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CAS RN: 52-24-4 | 产品编码: T4184
Thiotepa
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| 产品编码 | T4184 |
| 纯度/分析方法 | >95.0%(HPLC) |
| 分子式/分子量 | C__6H__1__2N__3PS = 189.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 52-24-4 |
| Reaxys-RN | 145978 |
| MDL编号 | MFCD00145452 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 52.0 to 56.0 °C |
| Water | max. 2.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 54 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | SZ2975000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | II |
| HS编码* | 2933.99-000 |
应用
Thiotepa: An Alkylating Cytotoxic Agent with a Broad Spectrum of Antitumor Activity
Thiotepa (ThioTEPA) is a trifunctional alkylating cytotoxic agent with a broad spectrum of antitumor activity. It is thought to inhibit tumor growth by inhibiting DNA synthesis.1) The major DNA bond cleavages are initiated by alkylation of guanine and adenine at the N-7 position, which breaks the bond between the purine base and the sugar, releasing alkylated guanines and adenines.2) (The product is for research purpose only.)
References
- 1) Chemistry, pharmacology and pharmacokinetics of N,N',N" - triethylenethiophosphoramide triethylenethiophosphoramide (ThioTEPA) (a review)
- 2) Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases: Thermodynamics and Bond Evolution Theory Analysis
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