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CAS RN: 13957-31-8 | 产品编码: T4059
4-Thiouridine
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纯度/分析方法: >95.0%(qNMR)
别名：
- 4-硫代尿苷
- 1-β-D-吡喃核糖基-4-硫代-3,4-二氢-2(1H)-嘧啶二酮
- 1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-4-硫代-3,4-二氢嘧啶-2(1H)-酮
- 1-β-D-Ribofuranosyl-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
产品文档：
| 产品编码 | T4059 |
| 纯度/分析方法 | >95.0%(qNMR) |
| 分子式/分子量 | C__9H__1__2N__2O__5S = 260.26 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 13957-31-8 |
| Reaxys-RN | 28750 |
| MDL编号 | MFCD00006538 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 140 °C |
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
4-Thiouridine: A Photoactive Ribonucleoside Analog Used for RNA Analysis Methods
4-Thiouridine (s4U or 4sU) is a photoactive ribonucleoside analog found in transfer RNA (tRNA), and absorbs light at wavelengths longer than 320 nm and, thus, can be selectively photo-activated.1,2) Recently, 4-thiouridine has been widely used for RNA analysis methods based on the photo-activity, such as PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation)3-5) and SLAM seq (thiol (SH)-linked alkylation for the metabolic sequencing of RNA)6). (The product is for research purpose only.)
References
- 1) Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions (a review)
- 2) Site-specific RNA crosslinking with 4-thiouridine (a review)
- 3) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
- 4) PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 5) Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 6) Thiol-linked alkylation of RNA to assess expression dynamics
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