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CAS RN: 122292-85-7 | 产品编码: T3633
产品编码 | T3633 |
纯度/分析方法 | >98.0%(HPLC) |
分子式/分子量 | C__1__7H__2__2N__2O__3 = 302.37 |
外观与形状(20°C) | 固体 |
储存温度 | 冷冻 (<0°C) |
应避免的情况 | 加热 |
包装和容器 | 10MG-Glass Bottle with Plastic Insert (查看图片) |
CAS RN | 122292-85-7 |
Reaxys-RN | 5291762 |
PubChem物质ID | 354334997 |
技术规格
Appearance | White to Orange to Green powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Optical purity(LC) | min. 95.0 ee% |
物性(参考值)
比旋光度 [α]D | -133° (C=0.3,MeOH) |
GHS
象形图 | |
信号词 | Warning |
危险性说明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相关法规
运输信息
HS编码* | 2928.00-000 |
应用
(-)-Trichostatin A: The Less Active Enantiomer of Trichostatin A
(-)-Trichostatin A (S-enantiomer) is the less active enantiomer (distomer) of trichostatin A (R-enantiomer) [T2477] as a HDAC inhibitor. However, it has been reported that HDAC inhibition assays with R- and S-trichostatin A in 2016 showed that the R-enantiomer was a broad-range HDAC inhibitor, whereas the S-enantiomer had moderate selectivity for HDAC6.
References
- Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells
- Modulation of growth and differentiation of human colon carcinoma cells by histone deacetylase inhibitory trichostatins
- Structural insights into HDAC6 tubulin deacetylation and its selective inhibition
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