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CAS RN: 162635-04-3 | 产品编码: T3574
Temsirolimus
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 95.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.00005 mg/l 25 °C |
| 溶解性（可溶于） | 醇, 乙醇 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H360 : May damage fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | VE6257000 |
运输信息
| HS编码* | 2934.99-000 |
应用
Temsirolimus: An Inhibitor of Mammalian Target of Rapamycin (mTOR)
Temsirolimus (also called CCI-779) is an inhibitor of mammalian target of rapamycin (mTOR), a serine/threonine protein kinase. Temsirolimus, the C-42 hydroxyl group ester analog of rapamycin [R0097], possesses better water solubility. Similarly to rapamycin, temsirolimus forms a complex with FK506-binding protein-12 (FKBP-12), and this complex binds and specifically acts as an allosteric inhibitor of mTOR. Inhibition of mTOR activity interferes with tumor angiogenesis，and resulted in a G1 growth arrest in treated tumor cells. (The product is for research purpose only.)
References
- Temsirolimus, an Inhibitor of Mammalian Target of Rapamycin (a review)
- Current development of mTOR inhibitors as anticancer agents (a review)
- In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites
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