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CAS RN: 29767-20-2 | 产品编码: T3109
Teniposide
| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 20MG |
S$88.50
|
9 | ≥40 |
|
| 100MG |
S$301.50
|
11 | 7 |
|
| 产品编码 | T3109 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__3__2H__3__2O__1__3S = 656.66 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 20MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 29767-20-2 |
| Reaxys-RN | 7108452 |
| PubChem物质ID | 253662241 |
| Merck Index (14) | 9145 |
| MDL编号 | MFCD00866516 |
技术规格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -107.0 to -115.0 deg(C=1, CHCl3:MeOH=9:1) |
物性（参考值）
| 熔点 | 247 °C(dec.) |
| 比旋光度 [α]D | -111° (C=1,CHCl3:MeOH=9:1) |
| 最大吸收波长 | 283(MeOH) nm |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 5.9 mg/l 25 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | KC0180000 |
运输信息
| HS编码* | 2938.90-000 |
应用
Adeno-associated virus vector transduction enhancer
Teniposide exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
应用
Teniposide: An Inhibitor of Topoisomerase II
Teniposide (VM26) and etoposide (VP16-213) [E0675] are semisynthetic derivatives of podophyllotoxin [P1771], an alkaloid. Teniposide and teniposide are an inhibitor of topoisomerase II such as doxorubicin [D4193], daunorubicin [D4532]. Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Topoisomerase II inhibitors are potent inducers of double strand breaks in DNA, and can cause arrest in the cell cycle at the G2 stage. Therefore, topoisomerase II inhibitors are the most widely used anti-cancer agents. Teniposide is used for the treatment of acute lymphocytic leukemia (ALL). (The product is for research purpose only.)
References
- The podophyllotoxin derivatives VP16-213 and VM26 (a review)
- The clinical pharmacology of etoposide and teniposide (a review)
- Clinical applications of anticancer drugs targeted to topoisomerase II
- Podophyllotoxin (a review)
- Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents
参考文献
TCIMail
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