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CAS RN: 19542-67-7 | 产品编码: T2846
BAY 11-7082
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| 产品编码 | T2846 |
| 纯度/分析方法 | >98.0%(HPLC)(N) |
| 分子式/分子量 | C__1__0H__9NO__2S = 207.25 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 光,空气,加热 |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 19542-67-7 |
| Reaxys-RN | 2049371 |
| PubChem物质ID | 135727354 |
| MDL编号 | MFCD00712162 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 132.0 to 136.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 134 °C |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | UD1430000 |
运输信息
| HS编码* | 2930.90-900 |
应用
Bay 11-7082: An Inhibitor of NFκB and IκBα Phosphorylation
Bay 11-7082 and Bay 11-7085 [B4845] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.
References
- Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
- Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines andκprimary adult T-cell leukemia cells
- Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
- Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
- The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells
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