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CAS RN: 85622-93-1 | 产品编码: T2744
Temozolomide
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| 产品编码 | T2744 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__6H__6N__6O__2 = 194.15 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 500MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 85622-93-1 |
| Reaxys-RN | 5547136 |
| PubChem物质ID | 125307782 |
| Merck Index (14) | 9139 |
| MDL编号 | MFCD00866492 |
技术规格
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
物性（参考值）
| 熔点 | 206 °C(dec.) |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | NJ5927050 |
运输信息
| HS编码* | 2933.99-000 |
应用
Studies of the Antitumor Activity of Temozolomide
References
- Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials
- Temozolomide and treatment of malignant glioma
- H. S. Friedman, T. Kerby, H. Calvert, Clin. Cancer Res. 2000, 6, 2585.
- Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
- CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
- Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
- Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
参考文献
文章/手册
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