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CAS RN: 70-00-8 | 产品编码: T2511
Trifluorothymidine
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 100MG |
S$186.00
|
8 | ≥100 |
|
| 1G |
S$1,243.50
|
14 | 8 |
|
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | T2511 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__1F__3N__2O__5 = 296.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 湿气 (吸湿) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 70-00-8 |
| Reaxys-RN | 568095 |
| PubChem物质ID | 87560183 |
| Merck Index (14) | 9687 |
| MDL编号 | MFCD00006534 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +47.0 to +53.0 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 189 °C |
| 比旋光度 [α]D | 50° (C=1,H2O) |
| 水溶性 | 可溶 |
GHS
相关法规
| RTECS# | XP2087500 |
运输信息
| HS编码* | 2940.00-000 |
应用
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
应用
Trifluridine: A Fluorinated Pyrimidine Nucleoside with Anti-Herpesvirus and Antitumor Activities
Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. Thymidylate kinase (TK) is a key enzyme in the synthesis of thymidine-5'-monophosphate [T0845, di-Na salt], an essential precursor for DNA biosynthesis. Trifluridine is incorporated into (virus or tumor) DNA as its triphosphate via phosphorylation by thymidylate kinase (TK), ultimately suppressing DNA replication and inhibiting cell proliferation.1-4) Trifluridine has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and vaccinia virus.1-3) Recently, a combined antitumor agent TAS-102 (trifluridine with tipiracil, a thymidine phosphorylase inhibitor) has been used in clinical. Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. 4-6) (The product is for research purpose only.)
References
- 1) Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture
- 2) Trifluorothymidine (a review)
- 3) Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections
- 4) Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes
- 5) A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA
- 6) TAS-102, a novel antitumor agent: a review of the mechanism of action
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