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CAS RN: 4083-64-1 | 产品编码: T0998
p-Toluenesulfonyl Isocyanate
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 数量 |
|---|---|---|---|---|
| 25G |
S$30.00
|
6 | ≥60 |
|
| 100G |
S$57.00
|
1 | ≥40 |
|
| 500G |
S$135.00
|
1 | 请联系我们 |
|
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[注意事项]
本品在储存过程中可能产生一些白色固体。请收到后尽早使用。
技术规格
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(Neutralization titration) | min. 95.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | -2 °C |
| 沸点 | 130 °C/6 mmHg |
| 闪点 | 145 °C |
| 比重 | 1.30 |
| 折射率 | 1.53 |
| 溶解性（可溶于） | 丙酮, 甲苯 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H332 : Harmful if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 : May cause respiratory irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | DB9032000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Derivatization Reagent of Hydroxyl Group for LC-MS
References
- p-Toluenesulfonyl isocyanate as a novel derivatization reagent to enhance the electrospray ionization and its application in the determination of two stereo isomers of 3-hydroxyl-7-methyl-norethynodrel in plasma
- Development and validation of an LC?ESI/MS/MS method with precolumn derivatization for the determination of betulin in rat plasma
应用
A Novel Hydroxy Protecting Group: Sulfonylcarbamate Group
Typical Procedure:
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
[Protection of Hydroxy Groups]
To a solution of alcohol (1.0 mmol) in THF (5 mL), p-toluenesulfonyl isocyanate (1.1 mmol) is added at room temperature. The mixture is stirred under N2 atmosphere. After the starting material has disappeared by TLC analysis, (the mixture is extracted with EtOAc, and) the solvent is evaporated. The residue is purified by silica gel column chromatography to afford the product.
[Removal of the Protecting Group by Pyridine―MeOH]
A solution of sulfonylcarbamate (100 mg) in pyridine―MeOH (7 : 3, 5 mL) is stirred at 50 °C until the starting material is consumed. After evaporation, the residue is purified by silica gel column chromatography.
References
应用
Synthesis of N-Acylsulfonamides
Reference
参考文献
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