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CAS RN: 95-95-4 | 产品编码: T0389
2,4,5-Trichlorophenol
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 64.0 to 68.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 67 °C |
| 沸点 | 115 °C/10 mmHg |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 100 mg/l |
| 溶解性（可溶于） | 醇, 苯, 乙醚 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. H335 : May cause respiratory irritation. H336 : May cause drowsiness or dizziness. H410 : Very toxic to aquatic life with long lasting effects. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相关法规
| RTECS# | SN1400000 |
运输信息
| UN编号 | UN2020 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2908.19-000 |
应用
A condensation Reaction via an Activated Ester
Experimental procedure: A mixture of DCC (1 mmol) and 2,4,5-trichlorophenol (1 mmol) in DMF (50 mL) is cooled to －10 °C and treated dropwise with a solution of cyclopentane carboxylic acid (1 mmol) in DMF (10 mL). The reaction mixture is allowed to warm to room temperature and is stirred overnight. Removal of the solvent under reduced pressure affords a white solid. The solid is triturated with ethyl acetate (50 mL), and the dicyclohexylurea is removed by filtration. Filtrate is evaporated under reduced pressure to afford oil. Flash chromatography on silica gel using EtOAc/hexanes (1:9) gives an active ester (1) in 88% yield.
A solution of 1 (1 mmol) in EtOAc (10 mL) is added dropwise to substituted L-histidine methyl ester (1 mmol) in EtOAc (50 mL) during 15 min, and the reaction mixture is stirred at ambient temperature for 24 h. Complete removal of the solvent in vacuo gives crude product. Flash column chromatography on silica gel using a solvent system of EtOAc/CH3OH (94:6) provides 2 (yield is not shown).
A solution of 1 (1 mmol) in EtOAc (10 mL) is added dropwise to substituted L-histidine methyl ester (1 mmol) in EtOAc (50 mL) during 15 min, and the reaction mixture is stirred at ambient temperature for 24 h. Complete removal of the solvent in vacuo gives crude product. Flash column chromatography on silica gel using a solvent system of EtOAc/CH3OH (94:6) provides 2 (yield is not shown).
References
- Synthesis and Biology of New Thyrotropin-Releasing Hormone (TRH) Analogues
参考文献