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CAS RN: 154-42-7 | 产品编码: T0212
6-Thioguanine
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| 产品编码 | T0212 |
| 纯度/分析方法 | >95.0%(HPLC) |
| 分子式/分子量 | C__5H__5N__5S = 167.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 154-42-7 |
| Reaxys-RN | 1074099 |
| PubChem物质ID | 87576202 |
| SDBS (AIST Spectral DB) | 4204 |
| Merck Index (14) | 9337 |
| MDL编号 | MFCD00233553 |
技术规格
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
物性（参考值）
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | UP0740000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.99-000 |
应用
6-Thioguanineis: A Cytotoxic Agent with Immunosuppressive and Antitumor Properties
6-Thioguanine (6-TG) is a cytotoxic agent with immunosuppressive and antitumor properties. In cell, 6-TG is converted to the active nucleotide metabolite by the enzyme hypoxanthine guanine phosphoribosyltransferase (HPRT), subsequently leading to inhibition of DNA/RNA synthesis.
References
- CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes
- The thiopurines: an update (a review)
- UVA photosensitization of thiopurines and skin cancer in organ transplant recipients (a review)
- 6-thioguanine: a drug with unrealized potential for cancer therapy (a review)
参考文献
文章/手册
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技术规格
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