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CAS RN: 2646-38-0 | 产品编码: S0941
Sodium Chenodeoxycholate
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| 产品编码 | S0941 |
| 纯度/分析方法 | >97.0%(GC) |
| 分子式/分子量 | C__2__4H__3__9NaO__4 = 414.56 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 2646-38-0 |
| Reaxys-RN | 4898788 |
| PubChem物质ID | 354333736 |
| MDL编号 | MFCD00065452 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Nonaqueous Titration) | min. 96.0 % |
物性（参考值）
| 熔点 | 298 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | FZ2231000 |
运输信息
| HS编码* | 2918.19-000 |
应用
Chenodeoxycholic Acid: A Naturally Occurring Bile Acid Having Suppressing Effects of Cholesterol and Cholic Acid Synthesis
Sodium chenodeoxycholate, a sodium salt of chenodeoxycholic acid, is a naturally occurring bile acid. Sodium chenodeoxycholate inhibits HMG-CoA-reductase and cholesterol-7α-hydroxylase, which are the rate-limiting step enzyme in cholesterol [C0318] and cholic acid [C0324] synthesis, respectively. Therefore, sodium chenodeoxycholate suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing chenodeoxycholic acid in an expanded bile acid pool. In clinical use, these actions would contribute to gradual dissolution of cholesterol gallstones. (The product is for research purpose only.)
References
- Induced alterations in the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in the hamster.
- The effect of chenodeoxycholic acid (CDCA) on cholesterol absorption
- Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use
- Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity (a review)
参考文献