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CAS RN: 17388-39-5 | 产品编码: S0897
Swertiamarin
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| 产品编码 | S0897 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__1__6H__2__2O__1__0 = 374.34 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 17388-39-5 |
| Reaxys-RN | 55278 |
| PubChem物质ID | 172088922 |
| Merck Index (14) | 9010 |
| MDL编号 | MFCD07783984 |
技术规格
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -136 to -141 deg(C=0.5、EtOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 114 °C |
| 比旋光度 [α]D | -138° (C=0.5,EtOH) |
| 最大吸收波长 | 238(MeOH) nm |
GHS
相关法规
| RTECS# | UQ1366700 |
运输信息
| HS编码* | 2938.90-000 |
应用
Swertiamarin: The Bitter Component of the Herb of Swertia japonica
Swertiamarin, a secoiridoid glycoside, is the bitter component of the herb of Swertia japonica.1) The main biosynthetic pathway of swertiamarin in the Gentianae is a route which leads from iridodial via deoxyloganic acid or loganic acid to secoiridoids.2) It has been reported that swertiamarin has diverse biological activities, including anti-inflammatory,3) anti-hyperlipidaemic,3) anti-nociceptive,4) hepatoprotective,4) anti-diabetic5-7) and antioxidant7) effects. (The product is for research purpose only)
References
- 1) Systematic review on xanthones and others isolates from genus Swertia
- A. Jamwal, Int. J. Pharm. Chem. Sci. 2012, 1, 1115.
- 2) Chemotaxonomy and pharmacology of Gentianaceae
- S. R. Jensen, J. Schripsema, in Gentianaceae: Systematics and Natural History, eds. by L. Struwe, V. A. Albert, Cambridge University Press, Cambridge, 2002, pp. 573-631.
- 3) Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3
- 4) Naturally occurring iridoids, secoiridoids. An updated review, part 4
- 5) Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin
- 6) Glycogen phosphorylase-a is a common target for anti-diabetic effect of iridoid and secoiridoid glycosides
- 7) A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases
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