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CAS RN: 68373-14-8 | 产品编码: S0868
Sulbactam
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +233.0 to +241.0 deg(C=1, H2O) |
物性（参考值）
| 熔点 | 156 °C(dec.) |
| 比旋光度 [α]D | 237° (C=1,H2O) |
| 水溶性 | 可溶 |
GHS
相关法规
运输信息
| HS编码* | 2941.10-000 |
应用
Sulbactam: A β-Lactamase Inhibitor Used with Another Antibiotic
Sulbactam and its sodium salt [U0159] are β-lactamase inhibitors which are chemically synthesized from 6-APA [A0800]. Although they have low antimicrobial activity, they inhibit enzymes (β-lactamases) which are produced by bacteria to degrade β-lactam antibiotics such as penicillins and cephalosporins. They are often used in combination with amoxicillin [A2099] or cefoperazone [C2768] to increase the antibiotic spectrum of theirs. (The product is for research purpose only.)
References
- Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases
- A Structure-Based Analysis of the Inhibition of Class A β-Lactamases by Sulbactam
- Inhibitor-resistant TEM β-lactamases: phenotypic, genetic and biochemical characteristics (a review)
- Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations (a review)
- Current challenges in antimicrobial chemotherapy: focus on β-lactamase inhibition (a review)
参考文献
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