Maximum quantity allowed is 999
请选择数量
CAS RN: 103628-48-4 | 产品编码: S0851
Sumatriptan Succinate
×
![]()
×
| 产品编码 | S0851 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__4H__2__1N__3O__2S·C__4H__6O__4 = 413.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 100MG-Glass Bottle with Plastic Insert （查看图片）, 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 103628-48-4 |
| 相关CAS RN | 103628-46-2 |
| Reaxys-RN | 5371868 |
| PubChem物质ID | 160871034 |
| Merck Index (14) | 8997 |
| MDL编号 | MFCD00902856 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 165.0 to 169.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 167 °C |
| 水溶性 | 可溶 |
| 在水中的溶解度 | 170 g/l 24 °C |
| 溶解性（不溶于） | 乙醚, 乙醇 |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H318 : Causes serious eye damage. |
| 防范说明 | P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
相关法规
| RTECS# | EJ9940000 |
运输信息
| HS编码* | 2935.90-000 |
应用
Sumatriptan Succinate: A Selective 5-HT1B/1D Receptor Agonist
Sumatriptan succinate is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Sumatriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), but has only a week affinity for a serotonergic receptor subtype (5-HT1A) and has no significant affinity for serotonergic receptor subtypes (5-HT1c, 5-HT2, 5-HT3) or for adrenergic (α1, α2, β), dopamine (D1, D2), muscarinic, or benzodiazepine receptors. Animal studies shows that sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. In addition, the transdermal iontophoretic patch of sumatriptan succinate is developed. (The product is for research purpose only.)
References
- Comparative Neuropharmacology of Dihydroergotamine and Sumatriptan (GR 43175)
- Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine(a review)
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate
- In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
- Review of Analytical Methods for Identification and Determination of Triptans (a review)
参考文献
TCIMail
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。