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CAS RN: 79559-97-0 | 产品编码: S0507
Sertraline Hydrochloride
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 盐酸舍曲林
- (1S,4S)-1-(3,4-二氯苯基)-1,2,3,4-四氢-4-(甲氨基)萘盐酸盐
- [(1S)-顺式]-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐
- (1S,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-L-萘胺盐酸盐
- 舍曲林盐酸盐
- (1S,4S)-1-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-4-(methylamino)naphthalene Hydrochloride
产品文档：
| 产品编码 | S0507 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__7H__1__7Cl__2N·HCl = 342.69 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 79559-97-0 |
| 相关CAS RN | 79617-96-2 |
| Reaxys-RN | 5783715 |
| PubChem物质ID | 87558859 |
| SDBS (AIST Spectral DB) | 51798 |
| Merck Index (14) | 8467 |
| MDL编号 | MFCD00895772 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 245.0 to 249.0 °C |
| Specific rotation [a]20/D | +35.0 to +41.0 deg(C=2,MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 245 °C |
| 比旋光度 [α]D | 38° (C=2,MeOH) |
| 溶解性（可溶于） | 甲醇 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | QJ0352070 |
运输信息
| HS编码* | 2921.49-000 |
应用
Sertraline Hydrochloride: A Selective Serotonin Reuptake Inhibitor (SSRI)
Sertraline hydrochloride is a selective serotonin (5-hydroxytryptamine; 5-HT [S0370]) reuptake inhibitor (SSRI) that has only very weak effects on norepinephrine [A0906] and dopamine [A0305] neuronal reuptake. in vitro studies have shown that sertraline has no significant affinity for adrenergic (α1, α2, β), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors. In addition, sertraline has minimal inhibitory effects on the major cytochrome P450 enzymes, and few drug-drug interactions of clinical significance have been documented. (The product is for research purpose only.)
References
- Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
- Review of sertraline and its clinical applications in psychiatric disorders (a review)
- Clinical pharmacokinetics of sertraline (a review)
- Sertraline hydrochloride (a review on preparation, physicochemical properties, methods of detection, stability and pharmacokinetics)
- Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometry
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
参考文献
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