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CAS RN: 56553-60-7 | 产品编码: S0394
Sodium Triacetoxyborohydride
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技术规格
| Appearance | White powder to crystal |
| Purity(NBS Method) | min. 80.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 106 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H318 : Causes serious eye damage. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. H228 : Flammable solid. H260 : In contact with water releases flammable gases which may ignite spontaneously. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P223 : Do not allow contact with water. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P240 : Ground and bond container and receiving equipment. P231 + P232 : Handle and store contents under inert gas. Protect from moisture. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P201 : Obtain special instructions before use. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P302 + P335 + P334 : IF ON SKIN: Brush off loose particles from skin. Immerse in cool water. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P402 + P404 : Store in a dry place. Store in a closed container. P405 : Store locked up. |
相关法规
运输信息
| UN编号 | UN3396 |
| 类别 | 4.3 / 4.1 |
| 包装类别 | II |
| HS编码* | 2915.39-000 |
应用
TCI Practical Example: Reductive Amination Reaction Using Sodium Triacetoxyborohydride
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Used Chemicals
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- m-Anisaldehyde [A0478]
- Dimethylamine Hydrochloride
- Sodium Acetate [S0559]
- Acetic Acid [A2035]
- Sodium Triacetoxyborohydride (= NaBH(OAc)3) [S0394]
- THF
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Procedure
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A solution of m-anisaldehyde (1.00 g, 7.34 mmol), dimethylamine hydrochloride (1.20 g, 14.7 mmol), sodium acetate (964 mg, 11.8 mmol) and acetic acid (253 µL, 4.41 mmol) in THF (30 mL) was stirred at 0 °C for 5 minutes and then sodium triacetoxyborohydride (3.42 g, 16.2 mmol) was added to the solution and stirred at room temperature for 1 hour. The reaction was quenched with sat. aq. NaHCO3 and the aqueous layer was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure and the residue was purified by NH silica gel column chromatography (ethyl acetate:hexane = 0:100 - 10:90) to give 1-(3-methoxyphenyl)-N,N-dimethylmethanamine as a colorless liquid (940 mg, 77% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by UPLC.
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Analytical Data
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1-(3-Methoxyphenyl)-N,N-dimethylmethanamine
1H NMR (270 MHz,DMSO); δ 7.22 (t, J = 7.8 Hz, 1H), 6.86-6.79 (m, 3H), 3.73 (s, 3H), 3.34 (s, 2H), 2.13 (s, 6H).
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Lead Reference
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- Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride
参考文献
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