Maximum quantity allowed is 999
请选择数量
CAS RN: 446859-33-2 | 产品编码: R0224
RepSox
×
![]()
×
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 193.0 to 197.0 °C |
物性（参考值）
| 熔点 | 195 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.99-000 |
应用
TGF-β Type I Receptor Inhibitor
RepSox (1) is a cell permeable TGF-β type I receptor inhibitor. 1 shows inhibition properties on ALK5 as shown in Table 1 and less potent activity against 9 other related kinases, including p38 MAPK, JNK1, and GSK3 (IC50 > 16 μM).1) 1 promotes reprogramming of human and mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).2,3) In addition, it was also reported that 1 induces human ESCs and iPSCs into glucagon-producing cells and insulin-producing cells, respectively.4,5)
References
- 1) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors
- 2) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
- 3) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
- 4) Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells
- 5) Production of functional glucagon-secreting α-cells from human embryonic stem cells
文章/手册
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。