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CAS RN: 99755-59-6 | 产品编码: R0220
Rotigotine
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| 产品编码 | R0220 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__2__5NOS = 315.48 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 10MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 99755-59-6 |
| Reaxys-RN | 5822772 |
| PubChem物质ID | 468592791 |
| MDL编号 | MFCD00869590 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -34.0 ～ -38.0 deg(C=1, methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 78 °C |
| 比旋光度 [α]D | -42.7° (C=1,MeOH) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 37.4 mg/l 25 °C |
| 溶解性（可溶于） | 乙醇, 二甲基甲酰胺 |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | QK4252968 |
运输信息
| HS编码* | 2934.99-000 |
应用
Rotigotinei: A Non-Ergot Dopamine Receptor Agonist
Rotigotinei is a non-ergot dopamine receptor agonist. Rotigotinei is used as a curative medicine via a transdermal system for Parkinson's disease and restless legs syndrome. The precise mechanism of action of rotigotinei is unknown, although it is thought to be related to its ability to stimulate dopamine receptors. (The product is for research purpose only.)
References
- The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease
- Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors
- Rotigotine transdermal patch: a review of its use in the treatment of Parkinson's disease
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