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CAS RN: 53123-88-9 | 产品编码: R0097
Rapamycin
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| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 25MG |
S$379.50
|
≥100 | 19 | 下单后约2周内可以发货 |
|
| 产品编码 | R0097 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__5__1H__7__9NO__1__3 = 914.19 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 25MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 53123-88-9 |
| Reaxys-RN | 5848501 |
| PubChem物质ID | 160871302 |
| Merck Index (14) | 8114 |
| MDL编号 | MFCD00867594 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 1.20 to 1.70 % |
| Specific rotation [a]20/D | -145 to -155 deg(C=0.2, MeOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 177 °C(dec.) |
| 比旋光度 [α]D | -150° (C=0.2,MeOH) |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 二甲基甲酰胺, 氯仿, 丙酮, 乙醚, 甲醇 |
GHS
| 象形图 |
|
| 信号词 | Warning |
| 危险性说明 | H371 : May cause damage to organs. H373 : May cause damage to organs through prolonged or repeated exposure. H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
相关法规
| RTECS# | VE6250000 |
运输信息
| HS编码* | 2941.90-000 |
应用
Bone research
References
- Regulation of bone formation using rapamycin-induced BMP2 expression system: influence of implanted cell number
- Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway
- Use of a Stringent Dimerizer-Regulated Gene Expression System for Controlled BMP2 Delivery
应用
Aggresome research
References
- Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition
- Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
- Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease
应用
Lentivirus vector transduction enhancer
Rapamycin improves lentiviral vector transduction efficiency of hematopoietic stem cells.1,2) Combination of Rapamycin with prostaglandin E2 further improves the efficiency.
References
- 1) Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
- 2) Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings
应用
Studies of mTOR (mammalian target of rapamycin) Inhibition
References
- mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
- Defining the role of mTOR in cancer
- Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
参考文献
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