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CAS RN: 50-55-5 | 产品编码: R0007
Reserpine
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| 产品编码 | R0007 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__3__3H__4__0N__2O__9 = 608.69 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 50-55-5 |
| Reaxys-RN | 102015 |
| PubChem物质ID | 87575589 |
| SDBS (AIST Spectral DB) | 10992 |
| Merck Index (14) | 8145 |
| MDL编号 | MFCD00005091 |
技术规格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -172 to -182 deg(C=1, DMF) |
物性（参考值）
| 比旋光度 [α]D | 177° (C=1,DMF) |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | ZG0350000 |
运输信息
| HS编码* | 2939.79-000 |
应用
Efflux pump inhibitor
Reserpine can potentially inhibit a diverse range of different efflux pumps, including the resistance nodulation division (RND) family. 1,2)
References
- 1) Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniae.
- 2) Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in gram-negative (ESKAPEE) bacteria
应用
Reserpine: A Central Nervous System Depressant and an Inhibitor of Multidrug Efflux Pumps in Bacteria
Reserpine is an alkaloid of rauwolfia sharing the yohimbine [Y0002] pentacyclic skeleton. Pharmacological studies have revealed that reserpine is a central nervous system depressant. Reserpine depletes stores of catecholamines (dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173]) and 5-hydroxytryptamine [S0370] by inhibiting their accumulation in many organs, including the brain and adrenal medulla. The depression of the central nervous system results in a decreased heart rate and a lowering of arterial blood pressure.
In addition, some studies have reported that reserpine enhances the in vitro activity of fluoroquinolones, such as norfloxacin [N0817], ciprofloxacin [C2227, C2510] and sparfloxacin [S0840], against strains of Staphylococcus aureus expressing distinct efflux-related multidrug resistance pumps. (The product is for research purpose only.)
In addition, some studies have reported that reserpine enhances the in vitro activity of fluoroquinolones, such as norfloxacin [N0817], ciprofloxacin [C2227, C2510] and sparfloxacin [S0840], against strains of Staphylococcus aureus expressing distinct efflux-related multidrug resistance pumps. (The product is for research purpose only.)
References
- Study of the relationship between the neurotransmitter store and adrenergic nerve block induced by reserpine and guanethidine
- The reserpine receptor (a review)
- How reserpine and chlorpromazine act: the impact of key discoveries on the history of psychopharmacology (a review)
- The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus
- A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus
- Reserpine (a review on the description, properties, degradation, metabolism, and analysis of reserpine)
应用
Reagen for myalgia model
References
- Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine
- F. Ponzio, G. Achilli, G. Calderini, P. Ferretti, C. Perego, G. Toffano, S. Algeri, Neurobiol. Aging. 1984, 5, 101.
- Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia
应用
Reagent for pain model
Reference
- Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia
应用
Reagent for schizophrenia model
References
- Electroconvulsive shock: sustained decrease in norepinephrine uptake affinity in a reserpine model of depression
- Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression
- Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association
- Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical Studies in the Rat
参考文献
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