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CAS RN: 56-54-2 | 产品编码: Q0006
Quinidine
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 169.0 to 174.0 °C |
| Specific rotation [a]20/D | +260 to +275 deg(C=1, EtOH) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 172 °C |
| 比旋光度 [α]D | 268° (C=1,EtOH) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 140 mg/l 25 °C |
| 溶解性（可溶于） | 苯, 醇, 氯仿 |
| 溶解性（微溶于） | 乙醚 |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | VA4725000 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2939.20-000 |
应用
Quinidine: A Class 1a Antiarrhythmic Agent
Quinidine, a cinchona alkaloid, originally derived from the bark of the Cinchona tree. Quinidine is a class 1a antiarrhythmic agent which interferes both with the sodium (Na+) and potassium (K+) channels, with a pharmacological profile of action similar to that of disopyramide [D2793]. Quinidine inhibits the fast inward sodium current, and depresses the conduction velocity. Consequently, quinidine decreases myocardial excitability. Its sulfate [Q0010] is used clinically. (The product is for research purpose only.)
References
- Quinidine (a review)
- Quinidine revisited (a review)
- Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs (a review)
参考文献
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化学品安全说明书(SDS)
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技术规格
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