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CAS RN: 391210-10-9 | 产品编码: P2897
PD 0325901
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纯度/分析方法: >97.0%(T)(HPLC)
别名：
- (R)-N-(2,3-二羟基丙氧基)-3,4-二氟-2-[(2-氟-4-碘苯基)氨基]苯甲酰胺
- N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-(2-氟-4-碘苯胺基)苯甲酰胺
- (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
- N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 10MG |
S$150.00
|
7 | 0 | 下单后约2周内可以发货 |
|
| 产品编码 | P2897 |
| 纯度/分析方法 | >97.0%(T)(HPLC) |
| 分子式/分子量 | C__1__6H__1__4F__3IN__2O__4 = 482.20 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (<0°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 391210-10-9 |
| Reaxys-RN | 11343179 |
| MDL编号 | MFCD08435926 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Volumetric Analysis) | min. 97.0 % |
| Melting point | 120.0 to 124.0 °C |
| Specific rotation | -2.0 to -3.5 deg(C=0.1, Methanol) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 123 °C |
GHS
相关法规
运输信息
| HS编码* | 2928.00-000 |
应用
PD 0325901: An Orally Active, Selective and Non-ATP-Competitive MEK (MAPKK) Inhibitor
The mitogen-activated protein kinase (MAPK) signaling pathway is involved in numerous cellular processes, including cell growth and differentiation. Phosphorylation of MAPK by MEK (MAPKK) leads to activation of this pathway, and is often overactive in some cancers. PD 0325901 is an orally active, selective and non-ATP-competitive MEK inhibitor that suppresses the phosphorylation of MAPK. In recent years, PD 0325901 has been investigated as a treatment for neurofibromatosis type1 (NF1). (The product is for research purpose only.)
References
- Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration
- The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
- Road to PD0325901 and beyond: The MEK Inhibitor Quest (a review)
- Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1
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