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CAS RN: 74150-27-9 | 产品编码: P2779
Pimobendan
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 匹莫苯丹
- 6-[2-(4-甲氧基苯基)-1H-苯并[d]咪唑-6-基]-5-甲基-4,5-二氢哒嗪-3(2H)-酮
- 6-[2-(4-甲氧基苯基)-1H-苯并咪唑-6-基]-5-甲基-4,5-二氢-3(2H)-哒嗪酮
- 6-[2-(4-Methoxyphenyl)-1H-benzo[d]imidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
产品文档：
| 产品编码 | P2779 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__9H__1__8N__4O__2 = 334.38 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 74150-27-9 |
| Reaxys-RN | 4207330 |
| PubChem物质ID | 468592720 |
| MDL编号 | MFCD00761648 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 249 °C(dec.) |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H302 : Harmful if swallowed. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相关法规
| RTECS# | UR6373000 |
运输信息
| HS编码* | 2933.99-000 |
应用
A Benzimidazole-Pyridazinone Derivative with Phosphodiesterase (Type III) Inhibition and Calcium-Sensitizing Properties
Pimobendan, a benzimidazole-pyridazinone derivative, is used as a veterinary cardiotonic vasodilator. It has been reported that pimobendan exerts its stimulatory myocardial effect by a dual mechanism of action: increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (Type III). (The product is for research purpose only.)
References
- Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties
- Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure (a review)
- Mechanisms of action of calcium-sensitizing drugs (a review)
- Mechanism of action of Ca2+ sensitizers - Update 2001
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