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CAS RN: 366-70-1 | 产品编码: P2550
Procarbazine Hydrochloride
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 % |
物性（参考值）
| 熔点 | 226 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | XS4725000 |
运输信息
| HS编码* | 2928.00-000 |
应用
Procarbazine: An Antitumor Alkylating Agent
Procarbazine is an antitumor alkylating agent that was first synthesized in the late 1950s. Reportedly, procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA, and the non-functioning t-RNA could cause the cessation of DNA, RNA, and protein synthesis.
In addition, procarbazine can also directly damage DNA through an alkylation reaction. Alkylating agents including procarbazine are known to be associated with production of reactive oxygen species (ROS) which may attack protein sulfhydryl groups contained in protein which is tightly bound to DNA. Procarbazine is not cross-resistant with other alkylating agents. Procarbazine has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's disease and brain tumors, since it can cross the blood-brain barrier. (The product is for research purpose only.)
In addition, procarbazine can also directly damage DNA through an alkylation reaction. Alkylating agents including procarbazine are known to be associated with production of reactive oxygen species (ROS) which may attack protein sulfhydryl groups contained in protein which is tightly bound to DNA. Procarbazine is not cross-resistant with other alkylating agents. Procarbazine has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's disease and brain tumors, since it can cross the blood-brain barrier. (The product is for research purpose only.)
References
- Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors (a review)
- The emerging role of reactive oxygen species in cancer therapy (a review)
- Procarbazine - a traditional drug in the treatment of malignant gliomas (a review)
- Procarbazine hydrochloride (a review on the physical properties, synthesis, stability, metabolites, toxicity, and methods of analysis)
- Determination of procarbazine in human plasma by liquid chromatography with electrospray ionization mass spectrometry
参考文献
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