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CAS RN: 566-65-4 | 产品编码: P2423
5α-Pregnane-3,20-dione
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| 产品编码 | P2423 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__2__1H__3__2O__2 = 316.49 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 566-65-4 |
| Reaxys-RN | 2058506 |
| PubChem物质ID | 468592596 |
| Merck Index (14) | 272 |
| MDL编号 | MFCD00067132 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 202.0 to 206.0 °C |
| Specific rotation [a]20/D | 113 to 123 deg(C=1, CHCL3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 204 °C |
| 比旋光度 [α]D | 118° (C=1,CHCl3) |
GHS
相关法规
| RTECS# | TU4157150 |
运输信息
| HS编码* | 2937.29-000 |
应用
5α-Pregnane-3,20-dione (5α-DHP): An Endogenous Neurosteroid
5α-Pregnane-3,20-dione (5α-DHP) is an endogenous progestogen and neurosteroid that is synthesized from progesterone [P0478] in the central and peripheral nervous system. 5α-DHP is also actively metabolized into neuroactive steroid metabolites, such as allopregnanolone and isopregnanolone. In addition, 5α-DHP is reported to act as a potent positive allosteric modulator of the action of γ-aminobutyric acid (GABA) at GABAA receptor.
References
- Neurosteroids: 3α-Hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats
- Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions (a review)
- Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection (a review)
- Gas chromatographic-mass fragmentographic quantitation of 3α-hydroxy-5α-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats
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