Maximum quantity allowed is 999
请选择数量
CAS RN: 39809-25-1 | 产品编码: P2164
Penciclovir
×
![]()
×
补充产品信息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 产品编码 | P2164 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__0H__1__5N__5O__3 = 253.26 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 200MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 39809-25-1 |
| Reaxys-RN | 4501039 |
| PubChem物质ID | 253662013 |
| Merck Index (14) | 7083 |
| MDL编号 | MFCD15142866 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 278 °C |
| 最大吸收波长 | 253(H2O) nm |
| 在水中的溶解度 | 1.7 g/l 20 °C |
GHS
相关法规
| RTECS# | UP0789400 |
运输信息
| HS编码* | 2933.99-000 |
应用
Penciclovir: An Antiherpesvirus Agent
Penciclovir, an acyclic guanine nucleoside analog, is an antiherpesvirus agent like acyclovir [A1915] . Famciclovir [F0842] is a prodrug of penciclovir. Penciclovir is active against most species in the herpesvirus family. It depends on the activity of the viral enzyme thymidine kinase (TK) to convert the agent to a monophosphate form and subsequently interfere with viral DNA replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to penciclovir, which has extremely low toxicity for human cell. The spectrum of activity of penciclovir against human herpesviruses is similar to that of acyclovir, both compounds having good activity against herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). Like acyclovir, penciclovir has slight activity against cytomegalovirus (CMV).
References
- Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) in cell culture
- Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus
- Antiviral portraits series. Number 3. Famciclovir and penciclovir. The mode of action of famciclovir including its conversion to penciclovir (a review)
- R. A. Vere Hodge, Antiviral Chem. Chemother. 1993, 4, 67.
- Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern (a review)
- M. R. Boyd, S. Safrin, E. R. Kern, Antiviral Chem. Chemother. 1993, 4, 3.
- The mode of action of penciclovir (a review)
- R. A. Vere Hodge, Y, C. Cheng, Antiviral Chem. Chemother. 1993, 4, 13.
- Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management
参考文献
文章/手册
TCIMail
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。