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CAS RN: 189028-93-1 | 产品编码: P2111
(S)-4-Phenyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-2-oxazolidinone
技术规格
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
Melting point | 90.0 to 94.0 °C |
Specific rotation [a]20/D | +49.0 to +54.0 deg(C=0.2, CHCL3) |
物性(参考值)
熔点 | 92 °C |
比旋光度 [α]D | 52° (C=0.2,CHCl3) |
溶解性(可溶于) | 丙酮 |
GHS
相关法规
运输信息
HS编码* | 2934.99-000 |
应用
An Intermediate in the Synthesis of Ezetimibe
This reagent is an intermediate in the synthesis of ezetimibe, which is a selective acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor used in hypercholesterolemia.
References
- Process for preparing Ezetimibe intermediate by an acid enhanced chemo- and enantioselective CBS catalyzed ketone reduction
- Process for preparing Ezetimibe intermediate by enantioselective CBS catalyzed ketone reduction with BH3-DEA prepared in situ
- Burkholderia cenocepacia: a new biocatalyst for efficient bioreduction of ezetimibe intermediate
- Lipase catalyzed kinetic resolution for the production of (S)-3-[5-(4-fluoro-phenyl)-5-hydroxy-pentanoyl]-4-phenyloxazolidin-2-one: An intermediate for the synthesis of ezetimibe
参考文献
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技术规格
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