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CAS RN: 101-26-8 | 产品编码: P1339
Pyridostigmine Bromide
技术规格
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 153.0 to 157.0 °C |
NMR | confirm to structure |
物性(参考值)
熔点 | 154 °C |
水溶性 | 可溶 |
溶解性(可溶于) | 醇 |
溶解性(不溶于) | 乙醚, 丙酮, 苯 |
GHS
象形图 | |
信号词 | Danger |
危险性说明 | H300 : Fatal if swallowed. |
防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
RTECS# | UU5270000 |
运输信息
UN编号 | UN2811 |
类别 | 6.1 |
包装类别 | II |
HS编码* | 2933.31-000 |
应用
Pyridostigmine Bromide: A Reversible Cholinesterase Inhibitor
Pyridostigmine bromide is a reversible cholinesterase inhibitor which inhibits the hydrolysis of acetylcholine (ACh) by competitive reversible binding to acetylcholinesterase (AChE). Pyridostigmine bromide is not through to enter the brain in significant amounts, and mainly activates peripheral cholinergic nervous system by increasing the concentration of ACh in the nerve through reversible inhibition of its hydrolysis by AChE. Pyridostigmine bromide is used for symptomatic treatment of myasthenia gravis and has been applied as a prophylaxis against nerve agents. (The product is for research purpose only.)
References
- Acetylcholinesterase inhibitors: a patent review (2008 - present)
- Treatment of myasthenia gravis: focus on pyridostigmine
- A validated HPLC method for the determination of pyridostigmine bromide, acetaminophen, acetylsalicylic acid and caffeine in rat plasma and urine
- Adsorptive stripping voltammetric determination of pyridostigmine bromide in bulk, pharmaceutical formulations and biological fluid
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