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CAS RN: 484-12-8 | 产品编码: O0426
Osthole
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| 产品编码 | O0426 |
| 纯度/分析方法 | >98.0%(GC) |
| 分子式/分子量 | C__1__5H__1__6O__3 = 244.29 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 484-12-8 |
| Reaxys-RN | 1288399 |
| PubChem物质ID | 253662100 |
| Merck Index (14) | 6895 |
| MDL编号 | MFCD00076049 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 82.0 to 86.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 84 °C |
| 最大吸收波长 | 322(MeOH) nm |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇 |
GHS
相关法规
| RTECS# | GN7700000 |
运输信息
| HS编码* | 2932.20-000 |
应用
Efflux pump inhibitor
References
- Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs
应用
A Crude Drug Ingredient in Cnidii Monnieri Fructus and etc.
Osthol is a natural coumarin that found in a variety of plants including Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol is an ingredient of a Traditional Chinese Medicine (TCM), and has received attention recently because of its significant and diverse pharmacological activities, including anticancer, anti-osteoporotic, and anti-proliferative activities. (The product is for research purpose only.)
References
- Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
- Anti-allergic effects of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) and Iits major component, osthol
- Coumarins from Cnidium monnieri and their antiosteoporotic activity
- Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study
- Osthole: a promising lead compound for drug discovery from a Traditional Chinese Medicine (TCM) (a review)
- Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review
参考文献
文章/手册
TCIMail
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)