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CAS RN: 63612-50-0 | 产品编码: N1212
Nilutamide
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- 尼鲁米特
- 5,5-二甲基-3-(4-硝基-3-(三氟甲基)苯基)咪唑烷-2,4-二酮
- 5,5-二甲基-3-[4-硝基-3-(三氟甲基)苯基]-2,4-咪唑烷二酮
- 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione
- 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 1G |
S$198.00
|
1 | 0 | 下单后约2周内可以发货 |
|
| 产品编码 | N1212 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__1__2H__1__0F__3N__3O__4 = 317.22 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 63612-50-0 |
| Reaxys-RN | 841906 |
| PubChem物质ID | 468592515 |
| MDL编号 | MFCD00864670 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Volumetric Analysis) | min. 98.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 155 °C |
GHS
| 象形图 |
|
| 信号词 | Danger |
| 危险性说明 | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | NI9453300 |
运输信息
| UN编号 | UN2811 |
| 类别 | 6.1 |
| 包装类别 | III |
| HS编码* | 2933.29-000 |
应用
Nilutamide: A Nonsteroidal Anti-Androgen
Nilutamide is a nonsteroidal anti-androgen with affinity for androgen receptors but not for progestogen, estrogen, or glucocorticoid receptors. In vivo, nilutamide preferentially binds to androgen receptors and blocks androgen receptor activation by testosterone and other androgens. Therefore, nilutamide is used in the treatment of prostate cancer, which is known to be androgen sensitive. (The product is for research purpose only.)
References
- Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer
- Receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity (a review)
- Square wave adsorptive stripping voltammetric determination of anticancer drug nilutamide nilutamide in biological fluids using cationic surfactant cetyltrimethylammonium bromide
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