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CAS RN: | 产品编码: M3544
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water) [for transcription] [for Molecular Biology]
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纯度/分析方法:
别名：
- N1-甲基假尿苷 5'-三磷酸钠 (约100 mM水溶液) [转录用] [用于分子生物学]
- [(2R,3S,4R,5S)-3,4-二羟基-5-(1-甲基-2,4-二氧代-1,2,3,4-四氢嘧啶-5-基)四氢呋喃-2-基]甲基四氢三磷酸钠 (约100 mM水溶液)
- [(2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl]methyl Tetrahydrogen Triphosphate Sodium Salt (ca. 100mM in Water)
产品文档：
| 产品编码 | M3544 |
| 分子式/分子量 | C__1__0H__1__7N__2O__1__5P__3·xNa |
| 外观与形状（20°C） | 液体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 加热 |
| 相关CAS RN | 1428903-59-6&1931922-77-8 |
技术规格
| Appearance | Colorless to Almost colorlessclear liquid |
| Purity(HPLC) | min. 95.0 area% |
| Concentration(HNMR) | 0.100 to 0.110 mol/L |
| DNase detection test | to pass test |
| RNase detection test | to pass test |
| Transcription test | to pass test |
| NMR | confirm to structure |
物性（参考值）
GHS
相关法规
运输信息
| HS编码* | 2934.99-000 |
应用
N1-Methylpseudouridine 5'-Triphosphate Sodium Salt (ca. 100mM in Water): A Modified Nucleotide for the Development of Next-Generation Vaccines
In recent years, numerous studies have demonstrated that mRNA has outstanding abilities to elicit potent immune responses, making it a viable new platform for the development of next-generation vaccines.1) There are further reports on the incorporation of modified nucleobases into mRNA which provide advantages for the generation of potent and long-lived antibody responses. This product is the 5'-triphosphate sodium salt of 1-methylpseudouridine (m1Ψ) [M3387] which enhances immune evasion, protein production, and consequently improves vaccine efficacy.2,3) We confirm that this product (m1Ψ-triphosphate) is used for the incorporation of it into mRNA by RNA polymerase, as well as transcription.
References
- 1) mRNA vaccine for cancer immunotherapy (a review)
- 2) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines (a review)
- 3) N1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells
参考文献
Please visit the Pubchem page at this link.
TCIMail
[Featured Products] RNA Base-modified Nucleoside Triphosphate for mRNA Medicine Development[Featured Products] Base-modified Ribonucleoside Triphosphates for mRNA Drug Discovery
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