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CAS RN: 595-33-5 | 产品编码: M1949
Megestrol Acetate
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| 产品编码 | M1949 |
| 纯度/分析方法 | >96.0%(HPLC) |
| 分子式/分子量 | C__2__4H__3__2O__4 = 384.52 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 室温 (15°C以下阴凉干燥处) |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 595-33-5 |
| Reaxys-RN | 1917291 |
| PubChem物质ID | 87560201 |
| Merck Index (14) | 5805 |
| MDL编号 | MFCD00056470 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Melting point | 213.0 to 220.0 °C |
| Specific rotation [a]20/D | +9.0 to +13.0 deg(C=2, CHCl3) |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 218 °C |
| 比旋光度 [α]D | 11° (C=2,CHCl3) |
| 溶解性（可溶于） | 氯仿 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H351 : Suspected of causing cancer. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | TU4075000 |
运输信息
| HS编码* | 2937.29-000 |
应用
Megestrol Acetate: A Semi-Synthetic Progestational Agent
Megestrol acetate and medroxyprogesterone acetate [M1964], semi-synthetic progestational agents, are effective hormonal treatments for metastatic breast cancer in postmenopausal women. The antineoplastic effect may result from inhibition of pituitary gonadotropin production and resultant decrease in estrogen secretion. Recently, megestrol acetate is often used for the treatment of anorexia and cachexia. The precise mechanism is unknown at the present time. (The product is for research purpose only.)
References
- Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate
- An overview of megestrol acetate for the treatment of advanced breast cancer (a review)
- Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate (a review)
- Treating malnutrition with megestrol acetate: literature review and review of our experience (a review)
- Trace analysis of androgens and progestogens in environmental waters by ultra-performance liquid chromatography-electrospray tandem mass spectrometry
参考文献
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