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CAS RN: 61-68-7 | 产品编码: M1782
Mefenamic Acid
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 230 °C |
GHS
| 象形图 |
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| 信号词 | Danger |
| 危险性说明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H371 : May cause damage to organs. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P263 : Avoid contact during pregnancy/ while nursing. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相关法规
| RTECS# | CB4550000 |
运输信息
| HS编码* | 2922.49-000 |
应用
Mefenamic Acid: A Non-Selective Non-Steroidal Anti-Inflammatory Drug (NSAID)
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. It is a non-selective cyclooxygenase (COX) inhibitor. COX directs the formation of several key mediators of inflammation called prostaglandins. Thus, mefenamic acid reduces the synthesis of prostaglandins. Mefenamic acid is metabolized principally by CYP2C9. Recently, some unique biological properties of mefenamic acid have also been reported. (The product is for research purpose only.)
References
- Inhibition of prostaglandin biosynthesis
- Selective COX-2 inhibitors: a review of their structure-activity relationships (a review)
- Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism
- The potential and promise of mefenamic acid (a review)
参考文献
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