Maintenance Notice (10:30 PM January 4 - 8:00 AM January 5, 2025 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
请选择数量
CAS RN: 192725-17-0 | 产品编码: L0377
Lopinavir
×
![]()
×
纯度/分析方法: >98.0%(HPLC)
别名：
- 洛匹那韦
- (S)-N-[(2S,4S,5S)-5-[2-(2,6-二甲基苯氧基)乙酰氨基]-4-羟基-1,6-二苯基己-2-基]-3-甲基-2-(2-氧代四氢嘧啶-1(2H)-基)丁酰胺
- (S)-N-[(2S,4S,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
产品文档：
| 产品编码 | L0377 |
| 纯度/分析方法 | >98.0%(HPLC) |
| 分子式/分子量 | C__3__7H__4__8N__4O__5 = 628.81 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 192725-17-0 |
| Reaxys-RN | 9309881 |
| PubChem物质ID | 468592179 |
| MDL编号 | MFCD22628840 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 103.0 to 107.0 °C |
| Specific rotation | -22.0.0 to -26.0.0 deg(C=0.4, mathanol |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 105 °C |
| 水溶性 | 不溶 |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
相关法规
| RTECS# | UV6264135 |
运输信息
| HS编码* | 2933.59-000 |
应用
Lopinavir: A HIV-1 Protease Inhibitor
Lopinavir (ABT-378), a HIV-1 protease inhibitor, prevents cleavage of the Gag-Pol polyprotein, resulting in the production of immature, non-infectious viral particles.1,2) In clinical, lopinavir is co-formulated with ritonavir [R0116] to enhance the bioavailability and pharmacokinetics of lopinavir.3) Ritonavir inhibits the CYP3A-mediated metabolism of lopinavir, thereby providing increased plasma levels of lopinavir. In the 2020s, it has been reported that lopinavir is an effective agent that inhibits the protease activity of corona viruses, such as SARS-CoV2 and MERS.4,5) (The product is for research purpose only.)
References
- 1) ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
- 2) Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus
- 3) Lopinavir-ritonavir: A new protease inhibitor (a review)
- 4) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
- 5) A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。