Maximum quantity allowed is 999
请选择数量
CAS RN: 156897-06-2 | 产品编码: L0348
Licofelone
×
![]()
×
纯度/分析方法: >95.0%(HPLC)
别名：
- 利克飞龙
- 2-[6-(4-氯苯基)-2,2-二甲基-7-苯基-2,3-二氢-1H-吡咯里嗪-5-基]乙酸
- [6-(4-氯苯基)-2,2-二甲基-7-苯基-2,3-二氢-1H-吡咯并[1,2-a]吡咯-5-基]乙酸
- ML-3000
- 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic Acid
- [6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrol-5-yl]acetic Acid
产品文档：
| 规格 | 单价 | 同一天 | 2-3个工作日 | 左侧以上货期 | 数量 |
货期信息
|
|---|---|---|---|---|---|---|
| 10MG |
S$241.50
|
≥40 | 0 | 下单后约2周内可以发货 |
|
| 产品编码 | L0348 |
| 纯度/分析方法 | >95.0%(HPLC) |
| 分子式/分子量 | C__2__3H__2__2ClNO__2 = 379.88 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷冻 (-20°C) |
| 应避免的情况 | 光,加热 |
| CAS RN | 156897-06-2 |
| Reaxys-RN | 6823674 |
| MDL编号 | MFCD00929900 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 157 °C |
GHS
相关法规
| RTECS# | UY7759650 |
运输信息
| HS编码* | 2933.99-000 |
应用
Licofelone: A Dual Inhibitor of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)
Licofelone (ML-3000) is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) metabolic pathways of arachidonic acid [A0781], and decreases the production of pro-inflammatory leukotrienes and prostaglandins.1-3) There are reports that licofelone is expected to possess clinical advantages over the selective inhibitors of COX enzyme. Licofelone is considered as a treatment for osteoarthritis. In addition, licofelone induces apoptosis in cancer cells.4,5) (The product is for research purpose only.)
References
- 1) Discovery and development of ML3000 (a review)
- 2) The pharmacological profile of ML3000: a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase (a review)
- 3) Licofelone -A novel analgesic and anti-inflammatory agent (a review)
- 4) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade
- 5) Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor
产品文档 (部分产品的分析图谱无法提供，敬请谅解。)
化学品安全说明书(SDS)
请选择语言。
如需更多帮助，请联系我 们。
技术规格
CoA及其他文档
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
示例 CoA
可下载CoA示例。注：该示例不一定是最新批次的CoA。
目前没有该产品的 CoA 示例。
分析图谱
请输入批号
批号输入有误。请输入中横线前的4-5个字母数字字符。
很抱歉，您搜索的分析图谱无法提供。