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CAS RN: 190791-29-8 | 产品编码: L0336
Lasofoxifene Tartrate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 185 °C(dec.) |
GHS
相关法规
| RTECS# | QK4252964 |
运输信息
| HS编码* | 2933.99-000 |
应用
Lasofoxifene tartrate: A Third-Generation, Non-Steroidal Selective Estrogen Receptor Modulator (SERM)
Lasofoxifene tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator (SERM). SERMs have the ability to provide mixed functional estrogen receptor (ER) agonist or antagonist activity, depending on the target tissue. Lasofoxifene has a remarkably improved oral bioavailability with respect to other SERMs, selectively binds to both ERα and ERβ with high affinity, and acts as a tissue selective estrogen antagonist or agonist.1-3) It has been reported that lasofoxifene prevents estrogen deficiency-induced bone loss, inhibits breast tumor formation and reduces serum cholesterol. In clinical, lasofoxifene tartrate has been used for the treatment of osteoporosis4) and breast cancer.5,6) (The product is for research purpose only.)
References
- 1) Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus, and body composition in rat models
- 2) Discovery and Preclinical Pharmacology of a Novel, Potent, Nonsteroidal Estrogen Receptor Agonist/Antagonist, CP-336156, a Diaryltetrahydronaphthalene
- 3) Lasofoxifene (CP-336,156), a selective estrogen receptor modulator, prevents bone loss induced by aging and orchidectomy in the adult rat
- 4) Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis (a review)
- 5) Preventive therapy for breast cancer: a consensus statement (a review)
- 6) The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice (a review)
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