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CAS RN: 75330-75-5 | 产品编码: L0214
Lovastatin
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技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 166.0 to 170.0 °C |
| Specific rotation [a]20/D | +320 to +340 deg(C=0.5, CH3CN) |
物性（参考值）
| 熔点 | 179 °C |
| 比旋光度 [α]D | 320° (C=0.5,CH3CN) |
| 水溶性 | 不溶 |
| 在水中的溶解度 | 0.4 mg/l 25 °C |
| 溶解性（可溶于） | 乙醇, 甲醇 |
GHS
| 危险性说明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相关法规
| RTECS# | EK7907000 |
运输信息
| HS编码* | 2932.20-000 |
应用
Lovastatin: A Potent HMG-CoA Reductase Inhibitor
Lovastatin is a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. It was first isolated from in a fermentation broth of Aspergillus terreus in 1978, and taken into clinical development as potential agents for lowering LDL cholesterol. Lovastatin is an inactive lactone which is readily hydrolyzed in vivo to the corresponding active beta-hydroxy acid. The active acid inhibits the action of enzyme HMG-CoA reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. (The product is for research purpose only.)
References
- Case history: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors (a review)
- Analysis of 5 HMG-CoA reductase inhibitors-atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies
- Chromatography-mass spectrometry methods for the quantitation of statins in biological samples (a review)
- Solubility of lovastatin in a family of six alcohols: ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol
应用
HMG-CoA Reductase Inhibitors (Statins)
Lovastatin is a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. It was first isolated from in a fermentation broth of Aspergillus terreus in 1978, and taken into clinical development as potential agents for lowering LDL cholesterol. Lovastatin is an inactive lactone which is readily hydrolyzed in vivo to the corresponding active beta-hydroxy acid. The active acid inhibits the action of enzyme HMG-CoA reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. (The product is for research purpose only.)
References
- Case history: Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors (a review)
- Analysis of 5 HMG-CoA reductase inhibitors-atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies
- Chromatography-mass spectrometry methods for the quantitation of statins in biological samples (a review)
- Solubility of lovastatin in a family of six alcohols: ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol
参考文献
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