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CAS RN: 7179-49-9 | 产品编码: L0166
Lincomycin Hydrochloride Monohydrate
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 151.0 to 157.0 °C |
| Specific rotation [a]20/D | +134 to +139 deg(C=1, H2O) |
| Solubility in Water | almost transparency |
| Water | 3.7 to 4.5 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 154 °C |
| 比旋光度 [α]D | 137° (C=1,H2O) |
GHS
相关法规
| RTECS# | RH6315500 |
运输信息
| HS编码* | 2941.90-000 |
应用
Lincomycin Hydrochloride: A Lincosamide Antibiotic with Activity against Anaerobic Bacteria
Lincomycin hydrochloride is a lincosamide antibiotic isolated from the actinomyces Streptomyces lincolnensis. A congener compound, clindamycin [C2256], is derived from lincomycin to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Lincomycin has broad activity against anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria with a few exceptions, but less activity against most aerobic Gram-negative bacteria. Lincomycin interacts with the 50s subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Bacterial resistance to clindamycin and lincomycin may be caused by methylation of bacterial 23S ribosomal RNA.
References
- Lincomycin related antibiotics (a review)
- Comparative metabolism of lincomycin in the swine, chicken, and rat (a review)
- Lincomycin, clindamycin and their applications (a review)
参考文献
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