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CAS RN: 921902-48-9 | 产品编码: K0077
KN3014
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纯度/分析方法: >98.0%(T)(HPLC)
别名：
- N-[2-(1-甲基-1,2,3,4-四氢喹啉-6-基)-2-(哌啶-1-基)乙基]-2-(邻甲苯氧基)乙酰胺
- 2-(2-甲基苯氧基)-N-[2-(1-甲基-1,2,3,4-四氢-6-喹啉基)-2-(1-哌啶基)乙基]乙酰胺
- N-[2-(1-Methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-(piperidin-1-yl)ethyl]-2-(o-tolyloxy)acetamide
- 2-(2-Methylphenoxy)-N-[2-(1-methyl-1,2,3,4-tetrahydro-6-quinolinyl)-2-(1-piperidinyl)ethyl]acetamide
产品文档：
| 产品编码 | K0077 |
纯度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__6H__3__5N__3O__2 = 421.59 |
| 外观与形状（20°C） | 固体 |
| 储存温度
|
冷藏 (0-10°C) |
| 储存在惰性气体下 | 存放于惰性气体之中 |
| 应避免的情况 | 空气,加热 |
| CAS RN | 921902-48-9 |
| Reaxys-RN | 38211687 |
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 138 °C |
GHS
相关法规
运输信息
| HS编码* | 2933.49-000 |
应用
KN3014: A Small Compound Targeting the Interaction between NLRP3-PYD and ASC-PYD of the NLRP3 Inflammasome
KN3014, developed by Masumoto et al, is a small compound containing a piperidine ring that directly inhibits the interaction between the PYDs (pyrin domains) of NLRP3 and ASC (apoptosis associated speck-like protein containing a caspase recruitment domain) by protein-protein interaction inhibition screening of wheat germ cell-free synthesized proteins.
References
- KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome
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