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CAS RN: 155270-99-8 | 产品编码: I1100
Istradefylline
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| 产品编码 | I1100 |
| 纯度/分析方法 | >98.0%(T)(HPLC) |
| 分子式/分子量 | C__2__0H__2__4N__4O__4 = 384.44 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| 包装和容器 | 1G-Glass Bottle with Plastic Insert （查看图片）, 250MG-Glass Bottle with Plastic Insert （查看图片） |
| CAS RN | 155270-99-8 |
| Reaxys-RN | 7863436 |
| PubChem物质ID | 468592093 |
| MDL编号 | MFCD00928421 |
技术规格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 191.0 to 195.0 °C |
物性（参考值）
| 熔点 | 193 °C |
| 最大吸收波长 | 362(CH2Cl2) nm |
| 水溶性 | 不溶 |
GHS
| 象形图 |
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| 信号词 | Warning |
| 危险性说明 | H361 : Suspected of damaging fertility or the unborn child. |
| 防范说明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相关法规
| RTECS# | UO8414732 |
运输信息
| HS编码* | 2933.99-000 |
应用
Istradefylline: A Selective Adenosine A2A Receptor Antagonist
Istradefylline (KW-6002) is a selective adenosine A2A receptor antagonist. Adenosine A2A receptors are a G protein-coupled receptor (GPCR), and also one of the receptors of adenosine. In the brain, adenosine A2A receptors are considered to be present specifically in the basal ganglia, and are thought to be involved in the regulation of motor functions. The degeneration or abnormality observed in Parkinson's disease (PD) is believed to occur in the basal ganglia. Istradefylline as a high affinity and selectivity for A2A receptors. Reportedly, istradefylline has improved motor function in patients with advanced PD including loss of L-DOPA [D0600] efficacy. (The product is for research purpose only.)
References
- Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys
- Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP
- Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson’s disease (a review)
- Istradefylline: First Global Approval (a review)
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